C. elegans models for neurodegenerative disease research offer a powerful platform to study the molecular and cellular mechanisms of disorders like Alzheimer’s, Parkinson’s, and ALS. These models are highly advantageous due to their genetic tractability, short lifespan, and conserved pathways. Researchers can use C. elegans to screen drug candidates, investigate protein aggregation, and explore neuroprotective strategies. This approach accelerates discoveries in neurodegeneration and supports the development of innovative therapies.